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We have investigated seven cases of large cell lymphomas (LCL) developing simultaneously or metachronously to nodular lymphocyte-predominant Hodgkin's disease (nodular paragranuloma, NP) for the presence of EBV and the chromosomal translocation t(14;18) by use of the polymerase chain reaction (PCR). The expression of the bcl-2 oncogene product in these cases and in five cases of progressive transformation of germinal centres as a potential precursor of NP was detected immunohistochemically with the monoclonal antibodies bcl-2-100 and bcl-2-124. All cases investigated were negative for EBV genomic material. The chromosomal translocation t(14;18) was also absent. Expression of the bcl-2 oncogene could be detected only in one case of nodular paragranuloma and in an unrelated case of LCL. Hence, LCL developing out of NP differ from other germinal center derived high-grade lymphomas.


Journal article


Verh Dtsch Ges Pathol

Publication Date





169 - 172


Adult, Aged, Antigens, Neoplasm, Antigens, Viral, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Epstein-Barr Virus Nuclear Antigens, Female, GTP-Binding Proteins, Genetic Variation, Herpesvirus 4, Human, Hodgkin Disease, Humans, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Nuclear Proteins, Oncogenes, Proliferating Cell Nuclear Antigen, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Translocation, Genetic