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The B-cell lymphoma/leukemia oncogene bcl-2 takes part in crucial regulatory events in B-cell maturation and differentiation. The reciprocal chromosomal translocation t(14;18), leading to overexpression of this oncogene, can be found in the majority of follicular lymphomas and much less frequently in B-cell leukemias and diffuse lymphomas. We have studied the expression of this protein in different subtypes of Hodgkin's disease using monoclonal antibodies directed against a formalin-resistant epitope of the bcl-2 protein and also have investigated these cases by polymerase chain reaction for evidence of the t(14;18) translocation. We were particularly interested to determine whether nodular paragranuloma (lymphocyte-predominant, nodular), which differs from other subtypes of Hodgkin's disease by virtue of the B-cell nature of its malignant cell population, is characterized by expression of the bcl-2 protein. Our data indicate that only a small number of nodular paragranulomas express the bcl-2 protein and that the expression is not specific for this type of Hodgkin's disease. In a smaller number of cases this expression of bcl-2 could be explained by the presence of the translocation t(14;18).

Type

Journal article

Journal

Hum Pathol

Publication Date

11/1992

Volume

23

Pages

1205 - 1209

Keywords

Antibodies, Monoclonal, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, Gene Expression, Hodgkin Disease, Humans, Immunoenzyme Techniques, Polymerase Chain Reaction, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Reed-Sternberg Cells, Translocation, Genetic