Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Acute lymphoblastic leukaemia/lymphoma is a malignant disorder derived from the clonal proliferation of lymphoid precursor cells. Whether the tumour cells are of B- or T-cell type is an important criterion for prognosis which has not been available previously to pathologists, due to the lack of a reliable early B-cell marker functioning on routinely processed material. This has changed with the production of monoclonal antibodies against the B-cell signalling molecule CD79a. CD79a is expressed on normal and neoplastic B cells from the early stages of B-cell maturation and has been considered to be B-cell-specific. Currently available antibodies against CD79a, in particular JCB117, allow the identification of B cells, and hence B lymphoblastic disease, in paraffin-embedded material. In this study, the expression of CD79a (JCB117) and CD3 has been investigated in 149 cases of T and 68 cases of B lymphoblastic leukaemia/lymphoma. For the first time, co-expression of CD79a (JCB117) and CD3 is reported in 10 per cent of cases of T lymphoblastic leukaemia/lymphoma. This finding raises questions about the co-expression of T- and B-cell markers in the development of lymphocytes, benign as well as malignant, and alerts pathologists to a potential problem in diagnosis.

Original publication

DOI

10.1002/(SICI)1096-9896(1998100)186:2<140::AID-PATH149>3.0.CO;2-Y

Type

Journal article

Journal

J Pathol

Publication Date

10/1998

Volume

186

Pages

140 - 143

Keywords

Antigens, CD, Antigens, Neoplasm, Biomarkers, Tumor, Blotting, Western, Burkitt Lymphoma, CD3 Complex, CD79 Antigens, Diagnosis, Differential, Gene Expression, Humans, Immunoenzyme Techniques, Immunophenotyping, Leukemia-Lymphoma, Adult T-Cell, Paraffin Embedding, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Receptors, Antigen, B-Cell