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A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.


Journal article


Hum Genet

Publication Date





142 - 146


Alleles Chromosome Mapping DNA/*genetics Female Genetic Markers Globins/*genetics Human Linkage (Genetics) Male *Nucleotide Mapping