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A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.

Type

Journal article

Journal

Hum Genet

Publication Date

1988

Volume

79

Pages

142 - 146

Keywords

Alleles Chromosome Mapping DNA/*genetics Female Genetic Markers Globins/*genetics Human Linkage (Genetics) Male *Nucleotide Mapping