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We have determined the molecular basis and frequency of alpha-thalassaemia in Nigeria. The alpha-thalassaemia determinant in this population is caused by only one type of single alpha globin gene deletion (-alpha 3.7). Comparison of the haematological features of those patients who have sickle-cell disease with (-alpha/alpha alpha, -alpha/-alpha) or without (alpha alpha/alpha alpha) alpha-thalassaemia showed similar trends to those reported in Jamaican and U.S. patients with these interactions. However, in contrast to studies in some other African populations we have shown that the frequency of alpha-thalassaemia in Nigeria is the same (0.24) in patients with or without homozygous sickle-cell disease (AA, AS and AC genotypes).

Type

Journal article

Journal

European journal of haematology

Publication Date

1987

Volume

38

Pages

370 - 375

Keywords

Adolescent Adult Anemia, Sickle Cell/*complications/genetics Child Chromosome Deletion Erythrocyte Indices Female Genetics, Population Genotype Globins/genetics Humans Male Nigeria Thalassemia/complications/*epidemiology/genetics