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Alpha-thalassemia is very common throughout all tropical and subtropical regions of the world. In Southeast Asia and the Mediterranean regions, compound heterozygotes and homozygotes may have anemia that is mild to severe (hemoglobin [Hb] H disease) or lethal (Hb Bart's hydrops fetalis). We have developed a reliable, single-tube multiplex-polymerase chain reaction (PCR) assay for the 6 most frequently observed determinants of alpha-thalassemia. The assay allows simple, high throughput genetic screening for these common hematological disorders. (Blood. 2000;95:360-362)

Type

Journal article

Journal

Blood

Publication Date

2000

Volume

95

Pages

360 - 362

Keywords

Base Sequence DNA/*blood DNA Primers Genetic Screening/*methods Globins/*genetics Heterozygote Homozygote Human Multigene Family Polymerase Chain Reaction/*methods *Sequence Deletion Support, Non-U.S. Gov't alpha-Thalassemia/*genetics