P106Loss of myocardial nNOS in human atrial fibrillation (AF) shortens action potential duration (APD) by increasing Ito: Implications for AF-induced electrical remodelling.
Liu X., Reilly S., Carnicer R., Recalde A., Krasopoulos G., Sayeed R., Desilva R., Casadei B.
Understanding the mechanism underlying atrial electrical remodelling in AF is of fundamental importance for the prevention and treatment of AF. We have recently found that neuronal nitric oxide synthase (nNOS) activity is dramatically reduced in atrial myocytes from patients with AF. Whether loss of nNOS activity contributes to AF-induced atrial electrical remodelling remains to be established.