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Dilation of the ascending aorta (AA) is associated with bicuspid aortic valve (BAV) disease and currently no medical therapy exists to delay or prevent AA dilatation in these patients. Inhibition of the renin-angiotensin system (RAS) appears toslow the rate of aortic dilatation in Marfan syndrome, but the effect on the aorta in BAV disease is unknown.We hypothesised that inhibition of the RAS in patients with BAV may reduce the rate of AA dilatation.

Original publication




Conference paper

Publication Date



100 Suppl 3


aortic stenosis, bicuspid aortic valve, ramipril