Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.
Mäkelä K-M., Traylor M., Oksala N., Kleber ME., Seppälä I., Lyytikäinen L-P., Hernesniemi JA., Kähönen M., Bevan S., Rothwell PM., Sudlow C., Dichgans M., Wellcome Trust Case Control Consortium 2 (WTCCC2) None., Delgado G., Grammer TB., Scharnagl H., Markus HS., März W., Lehtimäki T.
BACKGROUND AND PURPOSE: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). METHODS: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls). RESULTS: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. CONCLUSIONS: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.