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BACKGROUND: The use of coronary angiography (CA) for diagnosis and management of chest pain (CP) has several flaws. The assessment of coronary artery disease using fractional flow reserve (FFR) is a well-validated technique for describing lesion-level ischemia and improves clinical outcome in the context of percutaneous coronary intervention. The impact of routine FFR at the time of diagnostic CA on patient management has not been determined. METHODS AND RESULTS: Two hundred patients with stable CP underwent CA for clinical indications. The supervising cardiologist (S.C.) made a management plan based on CA (optimal medical therapy alone, percutaneous coronary intervention, coronary artery bypass grafting, or more information required) and also recorded which stenoses were significant. An interventional cardiologist then measured FFR in all patent coronary arteries of stentable diameter (≥2.25 mm). S.C. was then asked to make a second management plan when FFR results were disclosed. Overall, after disclosure of FFR data, management plan based on CA alone was changed in 26% of patients, and the number and localization of functional stenoses changed in 32%. Specifically, of 72 cases in which optimal medical therapy was recommended after CA, 9 (13%) were actually referred for revascularization with FFR data. By contrast, of 89 cases in whom management plan was optimal medical therapy based on FFR, revascularization would have been recommended in 25 (28%) based on CA. CONCLUSIONS: Routine measurement of FFR at CA has important influence both on which coronary arteries have significant stenoses and on patient management. These findings could have important implications for clinical practice. CLINICAL TRIAL REGISTRATION URL: Unique identifier: NCT01070771.

Original publication




Journal article


Circ Cardiovasc Interv

Publication Date





248 - 255


angiography, coronary disease, physiology, Aged, Chest Pain, Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease, Female, Fractional Flow Reserve, Myocardial, Humans, Incidence, Male, Middle Aged, Myocardial Ischemia, Percutaneous Coronary Intervention, Predictive Value of Tests, Treatment Outcome, United Kingdom