Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

MicroRNAs (miRNAs), a type of highly conserved small non-coding RNAs with an average length of 22 nucleotides, may serve as major regulators of gene expression and indispensable components of cellular gene expression networks. They have critical roles in normal biological processes and have been linked to many tumours, including hepatocellular carcinoma (HCC). HCC is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Viral hepatitis, caused by infection with hepatitis B or C viruses (HBV or HCV), can increase the risk of HCC and contributes to a significant disease burden around the world. Because of the variety of molecular alterations that may arise during the development and progression of HCC, standard of care and treatment for patients with HCC remains unsatisfactory. MiRNAs have been shown to participate in the pathogenesis of both HBV and HCV. In addition to a role in pathogenesis, miRNAs have significant clinical value in the early diagnosis of HCC since they are present in the blood and can be used as diagnostic markers and potential targets for specific systemic treatment.

Original publication

DOI

10.1136/postgradmedj-2013-131883

Type

Journal article

Journal

Postgrad Med J

Publication Date

02/2014

Volume

90

Pages

106 - 112

Keywords

Fibrosis, Hepatocellular Carcinoma, MicroRNA, Viral Hepatitis, Biomarkers, Tumor, Carcinoma, Hepatocellular, Disease Progression, Early Detection of Cancer, Female, Gene Expression Regulation, Neoplastic, Hepatitis, Viral, Human, Humans, Liver Cirrhosis, Liver Neoplasms, Male, MicroRNAs, Predictive Value of Tests, Prognosis