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DNA analyses of mouse X Chinese hamster somatic cell hybrids and of recombinant inbred mouse strains have previously shown that the interleukin-1 alpha and beta genes are tightly linked on murine chromosome 2, approximately 4.7 cM distal to beta-2-microglobulin. In this study, using in situ chromosome hybridization, we show that the two interleukin-1 genes are located in the F region of murine chromosome 2 and discuss this physical map position in relation to conserved genetic linkage groups.

Type

Journal article

Journal

Genomics

Publication Date

10/1989

Volume

5

Pages

481 - 485

Keywords

Animals, Chromosome Banding, Chromosome Mapping, Cricetinae, DNA, Genes, Interleukin-1, Karyotyping, Male, Mice, Mice, Inbred CBA