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INTRODUCTION: Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection. SCOPE: This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses.

Original publication

DOI

10.1007/s10875-010-9384-7

Type

Journal article

Journal

J Clin Immunol

Publication Date

07/2010

Volume

30

Pages

491 - 495

Keywords

DEAD Box Protein 58, DEAD-box RNA Helicases, Humans, Immunity, Innate, Interferon Type I, RNA Viruses, Receptors, Pattern Recognition, Virus Diseases