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Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulopathy and uncertainty about whether injury induces a unique coagulopathy when compared to other forms of major haemorrhage. This review describes current understanding of the coagulopathy of major blood loss and focuses on the early coagulation changes that occur following severe injury. It then reports on the contemporary management of coagulopathic bleeding using new transfusion strategies. Finally this review presents some practical points to the delivery of transfusion for major blood loss in the modern hospital setting.

Original publication

DOI

10.1016/j.blre.2012.06.004

Type

Journal article

Journal

Blood Rev

Publication Date

09/2012

Volume

26

Pages

223 - 232

Keywords

Blood Coagulation, Blood Coagulation Disorders, Blood Transfusion, Humans, Transfusion Reaction, Treatment Outcome, Wounds and Injuries