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A structural mathematical model of glucose-insulin relationships based on known quantitative responses of the major organs involved with glucose metabolism has been computed. Different degrees of beta-cell function and insulin sensitivity can be included, and the effect of their interaction assessed (i) in a steady state, basal homeostasis after an overnight fast and (ii) in response to a glucose infusion. By comparing a patient's basal plasma glucose and insulin (or C-peptide) concentrations with the predictions of a basal homeostatic model, the degree of impairment of beta-cell function and insulin sensitivity can be assessed. Similarly, the plasma glucose and insulin (or C-peptide) concentrations after a continuous glucose infusion can also be compared with predictions from the model to estimate beta-cell function and insulin sensitivity. These assessments of pathophysiology can be applied to data from individual patients or to patient populations.

Type

Journal article

Journal

Horm Metab Res Suppl

Publication Date

1990

Volume

24

Pages

66 - 71

Keywords

Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Glucose, Glucose Clamp Technique, Homeostasis, Humans, Insulin, Mathematics, Models, Biological