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Recent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with a higher proportion of repopulating cells, but also enhance CD34(+) cell mobilization when used in combination with G-CSF. Here, we review the importance of CXCR4 and its ligand CXCL12 in haemopoiesis, and the potential roles of CXCR4 antagonists in the clinical HSC transplant setting.

Original publication

DOI

10.1111/j.1423-0410.2007.00995.x

Type

Journal article

Journal

Vox Sang

Publication Date

01/2008

Volume

94

Pages

18 - 32

Keywords

Amino Acid Sequence, Chemokine CXCL12, Clinical Trials as Topic, Granulocyte Colony-Stimulating Factor, Hematologic Diseases, Hematopoiesis, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Humans, Models, Biological, Models, Molecular, Molecular Sequence Data, Receptors, CXCR, Receptors, CXCR4, Recombinant Proteins, Sequence Homology, Amino Acid