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Globally, hemoglobin (Hb) E beta thalassemia accounts for approximately half the severe forms of beta thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of Hb E beta thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition.

Original publication

DOI

10.1111/j.1749-6632.2010.05579.x

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

08/2010

Volume

1202

Pages

155 - 157

Keywords

Blood Transfusion, Hemoglobin E, Humans, beta-Thalassemia