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Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.

Original publication

DOI

10.1038/sj.gene.6363878

Type

Journal article

Journal

Genes Immun

Publication Date

09/2002

Volume

3

Pages

331 - 337

Keywords

Animals, Biological Evolution, Disease Models, Animal, Erythrocytes, Genetic Diseases, Inborn, Genetic Variation, HLA Antigens, Hemoglobins, Humans, Infection, Malaria, Mice