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Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates several steps of the reparative process occurring in ischaemic tissues, including sprouting angiogenesis, vessel maturation, interaction of vascular cells with recruited leucocytes and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis. © The Authors Journal compilation © 2009 Biochemical Society.

Original publication

DOI

10.1042/BST0371221

Type

Journal article

Journal

Biochemical Society Transactions

Publication Date

27/11/2009

Volume

37

Pages

1221 - 1227