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Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I-like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.

Original publication

DOI

10.1126/science.1185068

Type

Journal article

Journal

Science

Publication Date

15/01/2010

Volume

327

Pages

284 - 286

Keywords

Animals, Base Pairing, DEAD Box Protein 58, DEAD-box RNA Helicases, Genome, Viral, Humans, Immunity, Innate, Interferon-Induced Helicase, IFIH1, Interferons, Nucleic Acid Conformation, Protein Structure, Tertiary, RNA Virus Infections, RNA Viruses, RNA, Double-Stranded, RNA, Viral, Receptors, Pattern Recognition, Signal Transduction, Viral Proteins