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The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.

Original publication

DOI

10.1016/j.smim.2008.07.005

Type

Journal article

Journal

Semin Immunol

Publication Date

08/2008

Volume

20

Pages

213 - 220

Keywords

Adult Stem Cells, Animals, Cell Differentiation, Cell Lineage, Fetal Stem Cells, Hematopoietic Stem Cells, Humans, Models, Biological, Signal Transduction