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Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

Original publication

DOI

10.1126/science.1219179

Type

Journal article

Journal

Science

Publication Date

06/04/2012

Volume

336

Pages

86 - 90

Keywords

Animals, Cell Lineage, Cell Proliferation, Chick Embryo, Dendritic Cells, Embryo, Mammalian, Gene Deletion, Gene Expression Regulation, Developmental, Genes, myb, Hematopoietic Stem Cells, Kupffer Cells, Langerhans Cells, Liver, Macrophages, Mice, Microglia, Myeloid Cells, Myelopoiesis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-myb, Trans-Activators, Yolk Sac