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D-glucose reduces the outflow of manganese from pancreatic beta-cells in analogy to what has previously been reported for 45Ca. The decrease can be accounted for by an enhanced intracellular sequestration. The effect of D-glucose on manganese fluxes seems to be restricted to inhibition of the efflux; no stimulation of the influx being noted. The glucose-dependence of manganese uptake is hyperbolic with half maximal stimulation between 5 and 6 mM D-glucose.

Type

Journal article

Journal

Acta Biol Med Ger

Publication Date

1982

Volume

41

Pages

1221 - 1224

Keywords

Calcium, Glucose, Islets of Langerhans, Manganese