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Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.

Original publication




Journal article


Proc Natl Acad Sci U S A

Publication Date





11342 - 11346


Animals, Antigens, Viral, CD3 Complex, CD4-Positive T-Lymphocytes, CD8 Antigens, Gene Expression, Histocompatibility Antigens Class I, Lymph Nodes, Lymphocyte Activation, Mice, Mice, Transgenic, Nucleocapsid Proteins, Nucleoproteins, Orthomyxoviridae, Peptides, Receptors, Antigen, T-Cell, alpha-beta, Solubility, T-Lymphocyte Subsets, Thymus Gland, Viral Core Proteins