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The adhesion of Plasmodium falciparum-infected erythrocytes is thought to play a central role in the pathogenesis of severe malaria. ICAM-1 has been identified as one of the host receptors for parasitized erythrocytes and has been implicated as being involved in progression to cerebral malaria. Thus, intervention strategies based on the reversal of this interaction could potentially be used to reduce morbidity and mortality. We have investigated the inhibition of the interaction between ICAM-1 and infected erythrocytes by using recombinant soluble ICAM-1 as competitor and find that we are unable to reduce adhesion to ICAM-1 in vitro.

Type

Journal article

Journal

Infect Immun

Publication Date

11/1997

Volume

65

Pages

4580 - 4585

Keywords

Animals, COS Cells, Cell Adhesion, Erythrocytes, Intercellular Adhesion Molecule-1, Plasmodium falciparum, Recombinant Proteins