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The pancreatic beta cell serves as the fuel sensor of the entire body and controls, via secretion of the hypoglycaemic hormone insulin, the blood glucose concentrations within narrow limits by regulation of glucose uptake and release. During the last 30 years, a combination of biochemical and ultrastructural approaches has resulted in dramatic progress in the understanding of the processes by which glucose and other nutrients modulate the release of insulin. The beta cells have also been investigated using electrophysiological techniques and were thus found to be electrically excitable and to undergo complex changes in their membrane potential when exposed to glucose and other stimulators of secretion. The application of the patch-clamp technique to the pancreatic islet preparations has revolutionized the understanding of how bioelectrical processes participate in the fuel-sensing of the beta cell. An important achievement was the identification of an ATP-sensitive K(+)-channel as the resting and glucose-sensitive membrane conductance of the beta cell. This channel also constitutes the target of the hypoglycaemic sulphonylureas: a group of compounds which have been used successfully in the treatment of insulin-dependent diabetes mellitus for several decades.

Original publication

DOI

10.1007/s001250050706

Type

Journal article

Journal

Diabetologia

Publication Date

05/1997

Volume

40

Pages

487 - 495

Keywords

Animals, Blood Glucose, Calcium, Diabetes Mellitus, Electrophysiology, Exocytosis, Glucose, Homeostasis, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Islets of Langerhans, Membrane Potentials, Models, Biological, Potassium Channels, Sulfonylurea Compounds