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A case of severe haemolysis following an ABO unmatched renal transplant is reported in a group A nonsecretor who received a kidney from a group O living related donor. Following the haemolytic episode, group A donor units were incompatible and the patient was transfused with group O blood. Serological investigation of the recipient revealed anti-A present in the serum and on the red cells. Investigation of the donor revealed the presence of high-titre anti-A. The association of such high-titre donor antibody with haemolysis in ABO unmatched grafts has not been reported before. We discuss the risk factors for developing haemolysis in an ABO unmatched organ transplant and explore the possible relevance of such high donor antibody titre to recipients who are nonsecretors.

Original publication

DOI

10.1046/j.1365-3148.2000.00236.x

Type

Journal article

Journal

Transfus Med

Publication Date

03/2000

Volume

10

Pages

87 - 89

Keywords

ABO Blood-Group System, Adult, Hemolysis, Histocompatibility Testing, Humans, Kidney Transplantation, Male, Transplantation Immunology, Transplantation, Homologous