Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVES: We investigated the effect of shunt surgery in patients with Normal Pressure Hydrocephalus (NPH) using Single Photon Emission Computerised Tomography (SPECT). MATERIALS & METHODS: Thirteen patients diagnosed with NPH were assessed clinically and using (99m Tc)-SPECT and MRI both pre- and post-operatively. Regions of interest were placed manually on T2 MRI and transferred to co-registered SPECT. Differences between pre- and post-operative cerebellum-normalised regional cerebral blood flow (rCBF) were calculated and analysed in relation to clinical findings represented by a new disability scale. RESULTS: The patients presented initially with 50 +/- 30% disability score and improved following the surgery by 6 +/- 10% (p = 0.1). We did not observe any significant rCBF changes in the whole group of patients (overall rCBF difference = -0.3%, p = 0.4). Some improvement was in basal frontal lateral cortex, basal ganglia and thalamus (+5%, p = 0.08 to 0.2). Patients with <30% disability score initially (N = 4) had a reversed pattern of changes compared to those with more symptoms (p < 0.05). CONCLUSIONS: The small patient sample failed to show significant changes in rCBF due to NPH or surgery. There is indication that in patients with good initial clinical presentation there is little space for relevant clinical improvement and increase in rCBF.


Journal article


Acta Neurochir Suppl

Publication Date





169 - 172


Adult, Aged, Blood Flow Velocity, Brain, Cerebrovascular Circulation, Female, Humans, Hydrocephalus, Image Interpretation, Computer-Assisted, Male, Middle Aged, Postoperative Care, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Treatment Outcome