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Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

Type

Journal article

Journal

News Physiol Sci

Publication Date

04/2000

Volume

15

Pages

72 - 77