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Spontaneously beating atrial preparations, from rats fed different lipid diets, were compressed to 10 MPa. The following observations were made: Different lipid diets altered the ratio of omega-6/omega-3 polyunsaturated fatty acids of the cardiac phospholipids. Beating frequency and twitch tension at surface pressure was unaffected by the diets. Compression to 10 MPa caused a decrease in spontaneous beating frequency and an increased twitch tension in all preparations. The decrease in beating frequency was inversely related to the omega-6/omega-3 ratio. Pressure induced increase in twitch tension was not affected by the diets. N2O dissolved in the tissue bath solution partly counteracted the pressure-induced changes.


Journal article


Undersea Biomed Res

Publication Date





31 - 43


Animals, Dietary Fats, Female, Heart Atria, Heart Rate, Hydrostatic Pressure, Isometric Contraction, Membrane Lipids, Myocardial Contraction, Myocardium, Phospholipids, Pressure, Rats, Rats, Inbred Strains, Respiration