Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.

Type

Journal article

Journal

Parasitology

Publication Date

06/2004

Volume

128

Pages

577 - 584

Keywords

Animals, Erythrocytes, Flow Cytometry, Humans, Hypoxanthine, Lipoproteins, HDL, Lipoproteins, LDL, Malaria, Falciparum, Microscopy, Electron, Plasmodium falciparum