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PURPOSE: To investigate whether liver uptake of the iodinated hepatocyte-specific lipid emulsion FP 736-04 is altered by fatty infiltration of the liver. MATERIAL AND METHODS: Fatty infiltration of the liver was induced in female Sprague-Dawley rats by an intraperitoneal injection of L-ethionine preceded by 15 h of food withdrawal. CT of the liver was performed before and 24 h after the administration of L-ethionine and, in addition at the latter time point, after an i.v. injection of 1.0 ml/kg b.w. of FP 736-04. A control group was subjected to the same CT examination protocol. RESULTS: Intraperitoneal administration of L-ethionine caused liver steatosis, as established by liver triglyceride analysis, leading to a significant decrease in the liver attenuation, from 69.2 +/- 2.4 to 27.8 +/- 12.0 HU. The uptake of FP 736-04 by the fatty liver was significantly reduced, yielding a maximum enhancement of 22.3 +/- 7.9 HU as compared to a value of 32.3 +/- 5.0 HU in the control group. CONCLUSION: Enhancement by FP 736-04 was reduced in the steatotic liver compared with the normal liver. It remains to be established whether this degree of enhancement is sufficient for reliable lesion detection.


Journal article


Acta Radiol

Publication Date





405 - 409


Animals, Antimetabolites, Cholesterol, Contrast Media, Ethionine, Fat Emulsions, Intravenous, Fatty Liver, Female, Image Processing, Computer-Assisted, Injections, Intraperitoneal, Injections, Intravenous, Iodized Oil, Liver, Radiographic Image Enhancement, Rats, Rats, Sprague-Dawley, Regression Analysis, Tomography, X-Ray Computed, Triglycerides