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We report three new cases with a hematologic disorder and the unbalanced translocation der(1)t(1;7)(p11;p11). It has been speculated that the gene for the epidermal growth factor receptor, localized to the short arm of chromosome 7, might be amplified in cases with this translocation. We have demonstrated that there is no amplification of this gene in these three cases.


Journal article


Cancer Genet Cytogenet

Publication Date





91 - 95


Aged, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 7, ErbB Receptors, Female, Gene Amplification, Hematologic Diseases, Humans, Male, Middle Aged, Multiple Myeloma, Polycythemia Vera, Primary Myelofibrosis, Translocation, Genetic