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We report three new cases with a hematologic disorder and the unbalanced translocation der(1)t(1;7)(p11;p11). It has been speculated that the gene for the epidermal growth factor receptor, localized to the short arm of chromosome 7, might be amplified in cases with this translocation. We have demonstrated that there is no amplification of this gene in these three cases.

Type

Journal article

Journal

Cancer Genet Cytogenet

Publication Date

05/1991

Volume

53

Pages

91 - 95

Keywords

Aged, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 7, ErbB Receptors, Female, Gene Amplification, Hematologic Diseases, Humans, Male, Middle Aged, Multiple Myeloma, Polycythemia Vera, Primary Myelofibrosis, Translocation, Genetic