Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Patients with chronic heart failure (HF) are characterized by alterations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) levels. However, the impact of hypolipidemic and antioxidant treatment in MMPs and TIMPs is unknown. In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF. METHODS: Forty-two clinically stable patients with mild to moderate HF were randomized to receive rosuvastatin 10 mg or allopurinol 300 mg daily and followed up for 1 month. Serum levels of MMP-2, -9, TIMP-1, and -2 were measured before and after treatment. RESULTS: Levels of MMP-2 and -9 were significantly decreased in the rosuvastatin group (from 251±52 ng/ml and 400±206 ng/ml to 215±47 ng/ml and 309±166 ng/ml, p<0.001 and p<0.05 respectively), but not in the allopurinol group. In the rosuvastatin group, TIMP-2 levels were significantly increased (from 85±17 ng/ml to 93±16 ng/ml, p<0.05), while TIMP-1 remained unchanged. In the allopurinol group, no significant changes were observed regarding the levels of TIMPs. CONCLUSIONS: Short-term rosuvastatin but not allopurinol administration decreases MMP-2 and -9 and increases TIMP-2 levels.

Original publication

DOI

10.1016/j.ijcard.2009.05.051

Type

Journal article

Journal

Int J Cardiol

Publication Date

03/12/2010

Volume

145

Pages

438 - 443

Keywords

Aged, Allopurinol, Biomarkers, Chronic Disease, Drug Therapy, Combination, Extracellular Matrix, Female, Fluorobenzenes, Free Radical Scavengers, Heart Failure, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Middle Aged, Pyrimidines, Rosuvastatin Calcium, Sulfonamides, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2