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BACKGROUND: Heart failure has been associated with impaired endothelial function, increased inflammatory process and elevated oxidative stress status. Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis. AIM: To evaluate the effect of atorvastatin alone or in combination with vitamin E on endothelial function and serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and vascular cells adhesion molecule (sVCAM-1) in patients with ischemic heart failure. METHODS: Thirty-eight male patients with ischemic cardiomyopathy were randomly divided into three groups and received either atorvastatin 10 mg/day (n = 14), a combination of atorvastatin 10 mg/day plus vitamin E 400 IU/day (n = 12), or no statin or antioxidant treatment (n=12, controls) for 4 weeks. Forearm blood flow (FBF) was measured using venous occlusion strain-gauge plethysmography. Forearm vasodilatory response to reactive hyperemia (RH%) or to nitrate (NTG%) was defined as the percent change of FBF from rest to the maximum flow during reactive hyperemia or after nitrate administration, respectively. RESULTS: RH% was significantly improved in both the atorvastatin-treated (p < 0.01) and atorvastatin plus vitamin E groups (p < 0.05), but the increase was significantly higher in the atorvastatin-treated group (p < 0.05). Serum levels of IL-6, TNF-alpha and sVCAM-1 were decreased in the atorvastatin-treated group (p < 0.05 for all), but remained unaffected in the other two groups (p = NS for all). CONCLUSIONS: Low dose atorvastatin treatment improves endothelial function and reduces the expression of proinflammatory cytokines and adhesion molecules in patients with ischemic heart failure, an effect partly depressed by vitamin E.

Original publication

DOI

10.1016/j.ejheart.2005.03.007

Type

Journal article

Journal

Eur J Heart Fail

Publication Date

12/2005

Volume

7

Pages

1126 - 1132

Keywords

Aged, Antioxidants, Atorvastatin Calcium, Biomarkers, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Drug Therapy, Combination, Endothelium, Vascular, Follow-Up Studies, Heart Failure, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Interleukin-6, Male, Pyrroles, Treatment Outcome, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1, Vasodilation, Vitamin E