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OBJECTIVES: Recently, we reported that exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease is associated with enrichment of remnant lipoproteins with apolipoprotein C-I (apoC-I). In this study, the number and composition of chylomicron remnants and very low density lipoproteins (VLDLs) were examined in 30 asymptomatic normolipidemic 50-year-old men with and without early carotid atherosclerotic lesions. METHODS AND RESULTS: Intima-media thickness of the far wall of the common carotid artery was determined by B-mode ultrasound. Triglyceride-rich lipoproteins were subfractionated by density gradient ultracentrifugation and separated into VLDL and chylomicron remnant fractions by immunoaffinity chromatography. The postprandial triglyceridemia and increase in triglyceride-rich lipoprotein particle number (ie, apolipoprotein B concentrations) were not exaggerated in men with early atherosclerosis. In contrast, their large (Svedberg flotation rate 60 to 400) and small (Svedberg flotation rate 20 to 60) chylomicron remnants and VLDL were greatly enriched with apoC-I, and their small chylomicron remnants and VLDL particles were relatively enriched with cholesterol. Moreover, the number of apoC-I molecules on small chylomicron remnants was strongly associated with the degree of atherosclerosis. CONCLUSIONS: Early asymptomatic atherosclerosis in normolipidemic men without exaggerated postprandial triglyceridemia is associated with the enrichment of postprandial chylomicron and VLDL particles with apoC-I. Therefore, it is conceivable that the apoC-I content of lipoprotein remnants may serve as an early marker of coronary artery disease risk.

Type

Journal article

Journal

Arterioscler Thromb Vasc Biol

Publication Date

01/09/2002

Volume

22

Pages

1470 - 1474

Keywords

Apolipoprotein B-100, Apolipoprotein B-48, Apolipoprotein C-I, Apolipoproteins B, Apolipoproteins C, Arteriosclerosis, Biomarkers, Carotid Artery Diseases, Carotid Artery, Common, Cholesterol, Chylomicrons, Fasting, Humans, Lipids, Lipoproteins, Lipoproteins, VLDL, Male, Middle Aged, Population Surveillance, Postprandial Period, Sweden, Triglycerides, Tunica Intima, Tunica Media, Ultrasonography