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The gene causing MEN 1 has been localized to chromosome 11, band 11q13, by tumor deletion mapping studies and by family linkage studies. Molecular genetic markers flanking the MEN 1 gene have been defined, and they are of use in identifying disease gene carriers in a family. These individuals, who are at a high risk of developing the tumors of MEN 1, should undergo regular biochemical screening to detect the early onset of the disease. This combined use of molecular genetic and biochemical screening will help to improve the management of patients with MEN 1.

Type

Journal article

Journal

Endocrinol Metab Clin North Am

Publication Date

03/1994

Volume

23

Pages

117 - 135

Keywords

Chromosome Deletion, Female, Genetic Linkage, Genetic Testing, Humans, Male, Multiple Endocrine Neoplasia, Pedigree