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OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV). METHODS: The CTLA-4 CT60 (exon 4), +49 (exon 1) and -318 (promoter region) genotypes were determined by PCR and restriction fragment length polymorphism (RFLP) in 222 white Caucasians of UK origin with SVV and 670 ethnically matched controls. RESULTS: The CTLA-4 exon 1 (+49) and 4 (CT60) polymorphisms are associated with SVV (+49: chi(2) = 10.965, P = 0.004; CT60: chi(2) = 12.017, P = 0.002). Both disease-susceptible and disease-protective haplotypes have been identified in this cohort, and their frequencies are similar in the subtypes of WG and microscopic polyangiitis. CONCLUSION: This study provides further evidence that CTLA-4, a susceptibility locus for a number of common autoimmune diseases, may also be involved in the development of ANCA-associated SVV.

Original publication

DOI

10.1093/rheumatology/kep280

Type

Journal article

Journal

Rheumatology (Oxford)

Publication Date

12/2009

Volume

48

Pages

1502 - 1505

Keywords

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antigens, CD, CTLA-4 Antigen, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Polymorphism, Single Nucleotide