Parameters for reliable results in genetic association studies in common disease.
Dahlman I., Eaves IA., Kosoy R., Morrison VA., Heward J., Gough SC., Allahabadia A., Franklyn JA., Tuomilehto J., Tuomilehto-Wolf E., Cucca F., Guja C., Ionescu-Tirgoviste C., Stevens H., Carr P., Nutland S., McKinney P., Shield JP., Wang W., Cordell HJ., Walker N., Todd JA., Concannon P.
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.