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It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

Original publication

DOI

10.1038/ng825

Type

Journal article

Journal

Nat Genet

Publication Date

02/2002

Volume

30

Pages

149 - 150

Keywords

3' Untranslated Regions, Databases, Genetic, Diabetes Mellitus, Type 1, Genetics, Population, Humans, Interleukin-12, Linkage Disequilibrium, Polymorphism, Single Nucleotide