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Case-control studies suggest that the CTLA-4 gene may be a susceptibility locus for Graves' disease. The previously reported A/G polymorphism at position 49 in exon 1 of the CTLA-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white Caucasian subjects with Graves' disease. The relationship between CTLA-4 genotype and severity of thyroid dysfunction at diagnosis was also investigated. An increase in frequency of the G (alanine) allele was seen in Graves' patients compared with control subjects (42% vs. 31.5%, respectively; corrected P<0.0002; odds ratio = 1.58), and a significant difference in the distribution of GG, GA, and AA genotypes was observed between the groups (chi2 = 21.7; corrected P<0.00003). Increased transmission of the G allele was seen from heterozygous parents to affected offspring compared to unaffected offspring (chi2 = 5.7; P = 0.025). Circulating free T4 concentrations at diagnosis were significantly associated with CTLA-4 genotype (F = 3.26; P = 0.04). These results support the hypothesis that CTLA-4 may play a role in regulating self-tolerance by the immune system and in the pathogenesis of autoimmune disorders such as Graves' disease.

Original publication

DOI

10.1210/jcem.84.7.5820

Type

Journal article

Journal

J Clin Endocrinol Metab

Publication Date

07/1999

Volume

84

Pages

2398 - 2401

Keywords

Abatacept, Alanine, Alleles, Antigens, CD, Antigens, Differentiation, CTLA-4 Antigen, Case-Control Studies, Chromosomes, Human, Pair 2, Exons, Genetic Predisposition to Disease, Genotype, Graves Disease, Humans, Immune Tolerance, Immunoconjugates, Polymorphism, Genetic, Thyroxine