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Graves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributions seems to vary between data sets and geographic populations. Genome-wide searches are beginning to identify new loci, including GD-1, GD-2, and GD-3, although these loci have only been found in one data set. Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes.

Type

Journal article

Journal

Endocrinol Metab Clin North Am

Publication Date

06/2000

Volume

29

Pages

255 - 266

Keywords

Abatacept, Antigens, CD, Antigens, Differentiation, CTLA-4 Antigen, Genetic Linkage, Genetic Predisposition to Disease, Graves Disease, HLA Antigens, Humans, Immunoconjugates, Major Histocompatibility Complex, T-Lymphocytes, Cytotoxic