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Up to half of patients with Graves' hyperthyroidism have signs of thyroid associated ophthalmopathy, but the factors that cause this disorder are unknown. We investigated two major genetic susceptibility loci for Graves' disease in ophthalmopathy; the MHC class II region and the cytotoxic T lymphocyte antigen-4 (CTLA4) gene. Allelic frequencies of these genes in patients with Graves' disease who did and did not have concurrent thyroid-associated ophthalmopathy did not differ, and are, therefore, unlikely to contribute to its development.

Type

Journal article

Journal

Lancet

Publication Date

22/09/2001

Volume

358

Pages

984 - 985

Keywords

Abatacept, Adult, Alleles, Antigens, CD, Antigens, Differentiation, CTLA-4 Antigen, Case-Control Studies, Female, Genes, MHC Class II, Genetic Predisposition to Disease, Genotype, Graves Disease, Humans, Immunoconjugates, Logistic Models, Male, Smoking