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Endothelin (ET-1) is a potent vasoconstrictor. We compared patterns of ET-1 in percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and correlated it with markers of inflammation. Patients with multivessel disease were enrolled in a prospective randomized study of PCI vs. on-pump CABG. Procedural myocardial injury was assessed biochemically (CK-MB) and with new late gadolinium enhancement (LGE) on magnetic resonance imaging (MRI) one week postprocedure. ET-1 was measured at baseline, 1 h, 6 h, 12 h, 24 h and one week postprocedure. Log ET-1 values were compared between PCI and CABG and between patients without significant myocardial injury. Measurement of ET-1 values was performed in 36 PCI and 31 CABG patients. Baseline ET-1 values were similar between PCI and CABG patients (0.91 ± 0.36 vs. 1.0 ± 49 pg/ml, P = 0.38). Peak values were reached at 1 h in PCI and at 24 h in CABG patients and patients undergoing CABG had significantly higher log ET-1 values at 6 h, 12 h and 24 h. ET-1 did not correlate with biochemical or morphological markers of myocardial injury or change of left ventricular ejection fraction (LV-EF) but good linear correlation between max logET-1 and max logCRP was found (r = 0.44, P = 0.0002). ET-1 rise is more pronounced in on-pump CABG and ET-1 production could be driven by periprocedural inflammatory reaction.

Original publication

DOI

10.1510/icvts.2011.278192

Type

Journal article

Journal

Interact Cardiovasc Thorac Surg

Publication Date

12/2011

Volume

13

Pages

585 - 589

Keywords

Aged, Analysis of Variance, Angioplasty, Balloon, Coronary, Biomarkers, Cardiopulmonary Bypass, Chi-Square Distribution, Contrast Media, Coronary Artery Bypass, Coronary Artery Disease, Creatine Kinase, MB Form, Endothelin-1, England, Female, Humans, Inflammation, Inflammation Mediators, Magnetic Resonance Imaging, Male, Middle Aged, Myocardial Infarction, Myocardium, Predictive Value of Tests, Prospective Studies, Stroke Volume, Time Factors, Treatment Outcome, Troponin I, Up-Regulation, Ventricular Function, Left