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Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.

Original publication




Journal article


Adv Biol Regul

Publication Date



Acute myeloid leukemia, Apoptosis, Cytokines secretion, Epigenetic regulation, Myelodysplastic Syndromes, Phosphoinositide signaling