Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Kisspeptin has well-established critical roles in the control of reproduction and fertility. Recently, evidence has emerged that suggests kisspeptin may have additional roles in the regulation of glucose homeostasis. Conflicting reports on the effects of kisspeptin on insulin secretion in animal models have been published, which cannot be fully accounted for by the different kisspeptin isoforms and range of kisspeptin doses used in these studies. Human studies have demonstrated associations between circulating kisspeptin levels and measures of insulin secretion and insulin resistance; and the only published interventional study has confirmed kisspeptin enhances glucose-stimulated insulin secretion in humans. Further studies are required to elucidate the mechanisms underlying the effects of kisspeptin on the pancreatic β-cell and to determine the therapeutic potential of kisspeptin receptor agonist in the treatment of disorders of glucose homeostasis.

Original publication

DOI

10.1055/s-0039-3400242

Type

Journal article

Journal

Seminars in reproductive medicine

Publication Date

05/2019

Volume

37

Pages

141 - 146

Addresses

Department of Medicine, Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.

Keywords

Animals, Humans, Glucose Metabolism Disorders, Insulin, Glucose, Homeostasis, Reproduction, Fertility, Kisspeptins, Receptors, Kisspeptin-1, Insulin Secretion