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The use of coronary physiology allows for rational decision making at the time of PCI, contributing to better patient outcomes. Yet, coronary physiology is only one aspect of optimal revascularization. State-of-the-art PCI must also consider other important aspects such as intracoronary imaging guidance and specific procedural expertise, as tested in the SYNTAX II study. In this review, we highlight the technical aspects pertaining to the use of physiology as used in that trial and offer a glimpse into the future with emerging physiologic metrics, including functional coronary angiography, which have already established themselves as useful indices to guide decision making.

Original publication




Journal article


Cardiol Clin

Publication Date





147 - 158


Coronary, Intervention, PCI, Percutaneous, Revascularization, SYNTAX II, Humans, Percutaneous Coronary Intervention, Coronary Artery Disease, Coronary Artery Bypass, Treatment Outcome, Coronary Angiography