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We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.

Original publication




Journal article


J Pediatric Infect Dis Soc

Publication Date





82 - 86


MMP-2, MMP-9, TIMP-1, TIMP-2, cerebrospinal fluid, matrix metalloproteinase, pediatric, tissue inhibitors of metalloproteinase, tuberculous meningitis, Adolescent, Case-Control Studies, Child, Child, Preschool, Female, Gelatinases, Humans, Infant, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Prognosis, Reference Values, Statistics, Nonparametric, Tuberculosis, Meningeal