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For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology.

Original publication

DOI

10.1016/j.mce.2009.09.014

Type

Journal article

Journal

Mol Cell Endocrinol

Publication Date

29/04/2010

Volume

318

Pages

61 - 68

Keywords

Adipocytes, Animals, Diabetes Mellitus, Humans, Insulin Resistance, Peroxisome Proliferator-Activated Receptors