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Lymphocyte proliferation and tumourigenesis are dependent on nucleotide synthesis to support DNA, RNA and phospholipid synthesis. Here, we identified that reprogramming of nucleotide metabolism as an important factor divides mantle cell lymphoma (MCL) into two groups with different transcriptional signalling pathways and varying prognoses. We establish a nucleotide metabolism-related prognostic model that includes six genes with different regression coefficients, which significantly predicts prognosis for MCL patients (p 

Original publication




Journal article


Br J Haematol

Publication Date





550 - 565


TP53 aberrancy, cytidine metabolism, dsDNA-cGAS-STING pathway, ibrutinib resistance, mantle cell lymphoma, prognosis, Humans, Adult, Lymphoma, Mantle-Cell, Drug Resistance, Neoplasm, Cytidine, Nucleotidyltransferases, Nucleotides