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Left ventricular outflow tract obstruction (LVOTO) is common in hypertrophic cardiomyopathy (HCM), but relationships between anatomical metrics and obstruction are poorly understood. We aimed to develop machine learning methods to evaluate LVOTO in HCM patients and quantify relationships between anatomical metrics and obstruction. This retrospective analysis of 1905 participants of the HCM Registry quantified 11 anatomical metrics derived from 14 landmarks automatically detected on the three-chamber long axis cine CMR images. Linear and logistic regression was used to quantify strengths of relationships with the presence of LVOTO (defined by resting Doppler pressure drop of > 30 mmHg), using the area under the receiver operating characteristic (AUC). Intraclass correlation coefficients between the network predictions and three independent observers showed similar agreement to that between observers. The distance from anterior mitral valve leaflet tip to basal septum (AML-BS) was most highly correlated with Doppler pressure drop (R2 = 0.19, p 

Original publication




Journal article


Int J Cardiovasc Imaging

Publication Date





2695 - 2705


Atlas shape analysis, Hypertrophic cardiomyopathy, LV outflow tract obstruction, Humans, Cardiomyopathy, Hypertrophic, Machine Learning, Magnetic Resonance Spectroscopy, Predictive Value of Tests, Retrospective Studies, Ventricular Outflow Obstruction